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KMID : 0624620110440060410
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BMB Reports
2011 Volume.44 No. 6 p.410 ~ p.414
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Effects of novel chalcone derivatives on α-glucosidase, dipeptidyl peptidase-4, and adipocyte differentiation in vitro
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Bak Eun-Jung
Park Hong-Gyu
Lee Choong-Hwan
Lee Tong-Il
Woo Gye-Hyeong
Na Young-Hwa
Yoo Yun-Jung
Cha Jeong-Heon
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Abstract
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Chana series are new chalcone derivatives. To evaluate the possibility of Chana series as therapeutic agents of type 2 diabetes, the inhibitory effects of Chana series on the activities of α-glucosidase and DPP-4 were investigated using in vitro enzyme assays, and their effects on adipocyte differentiation were investigated in C3H10T1/2 cells. Chana 1 and Chana 7 among the Chana series showed significant inhibition of α-glucosidase activity. In DPP-4 enzyme assay, Chana 1 exhibited the highest inhibitory activity while Chana 7 did not. In MTT assay, Chana 1 did not show significant cytotoxicity up to a concentration of 250 μM, whereas cytotoxicity was observed with Chana 7 at a concentration of 300 μM. In addition, Chana 1 induced adipocyte differentiation. Therefore, Chana 1 showed inhibitory effects on α-glucosidase and DPP-4 as well as a stimulatory effect on adipocyte differentiation, suggesting that Chana 1 may be a potential beneficial agent for the treatment of type 2 diabetes.
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KEYWORD
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Adipocyte differentiation, α-Glucosidase, Chalcone derivates, DPP-4
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